| Name | Phone |
| Animal Control (County) | 803-534-0045 |
| Arts Center (OCFAC) | 803-536-4074 |
| Birth Records (DHEC) | 803-533-7236 |
| Chamber of Commerce | 803-534-6821 |
| Cooperative Church Ministries of Orangeburg (CCMO) | 803-531-4913 |
| Council of Aging | 803-531-4663 |
| County Information | 803-533-6100 |
| Death Records (DHEC) | 803-533-7236 |
| Department of Juvenile Justice (DJJ) | 803-533-6270 |
| Department of Social Services (DSS) | 803-531-3101 |
| Highway Patrol | 803-531-6855 |
| Hospital (TRMC) | 803-395-2804 |
| Library (County) | 803-531-4636 |
| Motor Vehicles, Department of (DMV) | 803-531-6866 |
| Orangeburg Area Development Center (OADC) | 803-533-5872 |
| Orangeburg County Development Commission (OCDC) | 803-536-3333 |
| Post Office | 803-536-1720 |
| Probation and Parole | 803-533-6288 |
| Red Cross | 803-534-5735 or 803-536-5355 |
| Regional Medical Center, The (TRMC) | 803-395-2804 |
| Salvation Army | 803-534-0785 |
| Samaritan House | 803-516-0088 |
| Sheriff Department (Non-Emergency)Â | 803-533-5834 |
| Social Security Office | 803-531-1568 |
| SPCA | 803-536-3918 |
| Unemployment Office (Job Service) | 803-534-3336 |
| United Way | 803-733-5400 |
| Veterans' Affairs (County) | 803-533-6156 |
| Vital Statistics (DHEC) | 803-533-7236 |
| Voter's Registration (County) | 803-533-6213 |
| YMCA | 803-531-7416 |