| Name | Phone |
| Animal Control (County) | (803) 534-0045 |
| Arts Center (OCFAC) | (803) 536-4074 |
| Birth Records (DHEC) | (803) 533-7236 |
| Chamber of Commerce | (803) 534-6821 |
| Cooperative Church Ministries of Orangeburg (CCMO) | (803) 531-4913 |
| Council of Aging | (803) 531-4663 |
| County Information | (803) 533-6100 |
| Death Records (DHEC) | (803) 533-7236 |
| Department of Juvenile Justice (DJJ) | (803) 533-6270 |
| Department of Social Services (DSS) | (803) 531-3101 |
| Highway Patrol | (803) 531-6855 |
| Hospital (TRMC) | (803) 395-2804 |
| Library (County) | (803) 531-4636 |
| Motor Vehicles, Department of (DMV) | (803) 531-6866 |
| Orangeburg Area Development Center (OADC) | (803) 533-5871 |
| Orangeburg County Development Commission (OCDC) | (803) 536-3333 |
| Post Office | (803) 536-1720 |
| Probation and Parole | (803) 533-6288 |
| Red Cross | (803) 534-5735 |
| Regional Medical Center, The (TRMC) | (803) 395-2804 |
| Salvation Army | (803) 534-0785 |
| Samaritan House | (803) 516-0088 |
| Sheriff Department (Non-Emergency) | (803) 533-5834 |
| Social Security Office | (803) 531-1568 |
| SPCA | (803) 536-3918 |
| Unemployment Office (Job Service) | (803) 534-3336 |
| United Way | (803) 733-5400 |
| Veterans' Affairs (County) | (803) 533-6156 |
| Vital Statistics (DHEC) | (803) 533-7236 |
| Voter's Registration (County) | (803) 533-6210 |
| YMCA | (803) 531-7416 |